We are back! This is our fifth post on cosmetics and nutraceuticals and how systems biology and Anaxomics can be useful in these fields. If you have missed the previous posts, you might want to read them first. They are a general introduction to systems biology in the nutraceuticals and cosmetics areas, a summary about the Anaxomics’s cosmeceutic services, and a two-part explication of the application of the TPMS technology to the nutraceutical science, for health claim support or for hypothesis generation.

 

As with other products, cosmetics’ customers have become more exigent about personalized and more efficient products. In this way, several new products have emerged to resolve customers’ requirements. In the field of cosmetic creams, it is important to choose the best option for the user’s requirements, as there are many different types of skin (more or less dry, more or less wrinkled…).

Within Anaxomics’s scientific support services for the cosmetic industry, we have developed a method to differentiate skin types and design personalized treatments, which guarantees better results for cosmetic costumers. We use our innovative TPMS technology to generate virtual models that simulate human physiology or specific features thereof (such as the skin physiology), allowing us to test active cosmetic ingredients in them and thus predict their effects on real people. Among the many applications of the systems-biology approach to cosmetic science, there is the production of personalized creams, according to personal features affecting the skin structure, such as genes or phenotypic characteristics.

We performed a genetic personalization project for a third-party company creating personalized creams. The first step was to identify, through TPMS, SNPs affecting skin-age related features. After that, we determined a list of ingredients of interest to be included in cosmetic creams. Using again the TPMS technology, we identified the relationship between the possible ingredients with the physiological effect related to particular SNPs. Then, we designed a range of cosmetic products that are specifically tailored for each consumer based on an ensemble of genetic polymorphisms that define key age-related skin features. We also assessed the efficiency and safety profile of each combination of ingredients (i.e. cosmetic cream) in order to guarantee maximal quality to the cosmetics product line. As a result, a full complete cosmetic line emerged, being now available in market from our partner. The full process is summarized in the image below:

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Skin physiology and genetic polymorphisms are very complex networks, but they can be understood through Anaxomics’s conversion into information entered in our protein maps and mathematical models. This successful application of systems biology to personalize cosmetic products is one example of how Anaxomics can provide scientific knowledge and add value to new products, making them more competitive, not only in the pharma and biotech markets, or clinical drug development stages, but in any market related to human health, such as cosmetics and nutrition.

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