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Systems Biology approach to Cosmetics research
A number of cosmetic companies are exploring the use of growth factors like epidermal growth factor (EGF), fibroblast growth factor (FGF), interleukins (IL), and the similar, or even human growth hormones (hGH) to stimulate growth of the human skin cells for cosmetic uses.
- But there is a need to find optimal combinations of these compounds to:
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minimize the quantity used, as they are expensive
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find synergistic combinations that maximize the effect
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combine them with other cosmetic active compounds
Starting from the human skin interactions map, we have developed a network model that reproduces biochemical behaviour in the skin (metabolic, signalling and growing), and have created a "virtual mixer" that allows to simulate combinations of compounds to maximize desired effects.
Some of the predicted combinations have been tested in vitro and in clinical trials with optimal results.
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