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Relating Mechanism of Action and safety
Situation
Anaxomics has predicted potential negative effects of a certain very common prescription drug and of other drugs of the same family.
Anaxomics Strategy
Anaxomics created the biological network around neurodegenerative diseases pathways, and simulated effects of a collection of unrelated drugs. Unexpectedly, we predicted that a very common drug, used widely for a number of indications, was mechanistically related with amyloid protein accumulation.
We tested in vitro and in vivo our predictions in animal models.
Solution and Practical Use
Experimental results show a consistent dose-dependent response of the compound studied and of other similar compounds of the same family in provoking amyloid protein accumulation in brain in mice. This could have further epidemiological consequences in humans.
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