Nature Chemical Biology

Chemical tools are increasingly important for probing and manipulating complex biological systems, and systems-based approaches are a powerful way to understand the often pleiotropic biological effects of small molecules. In this issue we feature a collection of articles that highlight the emerging interface of chemical biology and systems biology.

The cover shows an artistic representation of the human interactome built with the network analysis package AxPathBuilder (http://www.anaxomics.com/). Spherical, multispherical and daisy-flower nodes in the network represent proteins, multiprotein complexes and pathways, respectively, and edges are physical interactions between these elements. Overlaid on this network are small molecules that exhibit polypharmacology (in white and blue) or that are synergistic in combination (in yellow). For full article, visit www.nature.com