Clinical practitioners have long known that patients vary widely in their responses to drug therapy, not only in obtaining therapeutic effect, but also in suffering from adverse drug reactions. Recent advancements in genomics have uncovered some of underlying molecular basis that explain these differences, leading to the creation of the term ‘pharmacogenomics’. Also, biomedical investigation has revealed that multifactorial diseases are caused by several pathophysiological mechanisms with variable contribution to the overall pathogenic process.
Anaxomics’ TPMS recreates this variability in the form of multiple mathematical algorithms that account for all the possible physiological responses (Figure 2). Thus, our system is able to predict the average behaviour of the entire population, but also other mechanisms of action that, while being less probable, are expected to be found in certain subpopulations. Therefore, when confronted with the myriad of therapeutic responses that appear in clinical scenarios, TPMS can elucidate the unique molecular mechanism that lead to them.